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Anemarsaponin B

Cat. No. M38986

All AbMole products are for research use only, cannot be used for human consumption.

Anemarsaponin B Structure

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Quality Control & Documentation
Biological Activity

Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα.

Chemical Information
Molecular Weight 903.06
Formula C45H74O18
CAS Number 139051-27-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jie Zhang et al. Pharm Biol. The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

[2] Mingwei Wang et al. Pharm Biol. Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes

[3] Bing-You Yang et al. Molecules. Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides

[4] Ji-Yeon Kim et al. Food Chem Toxicol. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways

[5] Luping Qin et al. J Ethnopharmacol. Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula

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Keywords: Anemarsaponin B supplier, NO Synthase, inhibitors, activators

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