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Amyloid beta-peptide(25-35)

Cat. No. M9071

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Amyloid beta-peptide(25-35) Structure
Synonym:

Aβ25-35; β-Amyloid peptide(25-35)

Size Price Availability Quantity
1mg USD 70  USD70 In stock
5mg USD 205  USD205 In stock
10mg USD 325  USD325 In stock
25mg USD 550  USD550 In stock
50mg USD 960  USD960 In stock
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Quality Control & Documentation
Biological Activity

Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells. Amyloid beta-peptide(25-35) is also investigated in gel state for the first time. Comparative studies are also carried out using vibrational absorption and ECD. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35.

In vivo, rats injected with Aβ25–35 peptide intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P < 0.05) and passive avoidance task (P < 0.01) compared to the AD model group.

Chemical Information
Molecular Weight 1060.27
Formula C45H81N13O14S
CAS Number 131602-53-4
Solubility (25°C) DMSO: ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Liu M, et al. BMC Complement Altern Med. Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease.

[2] Clementi ME, et al. FEBS Lett. Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35.

[3] DUrsi AM, et al. J Med Chem. Solution structure of amyloid beta-peptide (25-35) in different media.

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Keywords: Amyloid beta-peptide(25-35), Aβ25-35; β-Amyloid peptide(25-35) supplier, Amyloid, inhibitors, activators

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