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Amine-PEG3-Biotin

Cat. No. M13769
Amine-PEG3-Biotin Structure
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Biological Activity

Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group.

Chemical Information
Molecular Weight 418.55
CAS Number 359860-27-8
Solubility (25°C) DMSO 150 mg/mL
Water 90 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Huanshun Yin, et al. Biosens Bioelectron. Electrochemical immunosensor for N6-methyladenosine detection in human cell lines based on biotin-streptavidin system and silver-SiO 2 signal amplification

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