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AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM. AMG131 can be used for research of type-2 diabetes mellitus (T2DM).
| Molecular Weight | 514.21 |
| Formula | C21H12Cl4N2O3S |
| CAS Number | 315224-26-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 250 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Alykhan Motani, et al. J Mol Biol. INT131: a selective modulator of PPAR gamma
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