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AMG131

Cat. No. M29897

All AbMole products are for research use only, cannot be used for human consumption.

AMG131 Structure
Synonym:

INT131

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Quality Control & Documentation
Biological Activity

AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM. AMG131 can be used for research of type-2 diabetes mellitus (T2DM).

Chemical Information
Molecular Weight 514.21
Formula C21H12Cl4N2O3S
CAS Number 315224-26-1
Form Solid
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Stergios A Polyzos, et al. Metabolism. Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis

[2] Stergios A Polyzos, et al. Metabolism. Nonalcoholic fatty liver disease: Updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-γ agonists

[3] Alykhan Motani, et al. J Mol Biol. INT131: a selective modulator of PPAR gamma

[4] Linda S Higgins, et al. PPAR Res. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer

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Keywords: AMG131, INT131 supplier, PPAR, inhibitors, activators

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