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α-Hydroxyglutaric acid disodium

Cat. No. M30059

All AbMole products are for research use only, cannot be used for human consumption.

α-Hydroxyglutaric acid disodium Structure
Synonym:

2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium

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Quality Control & Documentation
Biological Activity

α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

Chemical Information
Molecular Weight 192.08
Formula C5H6Na2O5
CAS Number 40951-21-1
Form Solid
Solubility (25°C) Water 125 mg/mL (ultrasonic and warming and heat to 60°C)
Storage -20°C, dry, sealed
References

[1] Vianney Poinsignon, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Quantitation of isocitrate dehydrogenase (IDH)-induced D and L enantiomers of 2-hydroxyglutaric acid in biological fluids by a fully validated liquid tandem mass spectrometry method, suitable for clinical applications

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Keywords: α-Hydroxyglutaric acid disodium, 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium supplier, Histone demethylase, inhibitors, activators

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