Free shipping on all orders over $ 500

α-Hederin

Cat. No. M3967
α-Hederin Structure
Synonym:

Hed,alpha-hederin

Size Price Availability Quantity
20mg USD 450  USD450 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

α-Hederin stimulates NO release and is able to upregulate iNOS expression through NF-kappa B transactivation, which may be a mechanism, whereby α-Hederin elicits its biological effects.α-Hederin enhanced some nonenzymatic antioxidant components in liver, which play a partial role in Hed protection against hepatotoxicity produced by some chemicals.treatment of mice with α-Hederin decreases the levels and activities of several P450 enzymes.The suppression of P450 appears to be one of mechanisms by which alpha-hederin protects mice from the hepatotoxicity of some chemicals.It is possible to optimize colorectal cancer cell sensitivity to 5-FU with α-Hederin.

Chemical Information
Molecular Weight 750.96
Formula C41H66O12
CAS Number 27013-91-8
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sieben A, et al. Biochemistry. Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.

[2] Bun SS, et al. Phytother Res. Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells.

[3] Jeong HG, et al. Planta Med. Expression of inducible nitric oxide synthase by alpha-hederin in macrophages.

[4] Liu YP, et al. Zhongguo Yao Li Xue Bao. Effect of alpha-hederin on hepatic detoxifying systems in mice.

[5] Liu J, et al. Toxicol Appl Pharmacol. Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection.

Related Apoptosis Products
Cytochrome C (from Pig Heart)

Cytochrome C (from Pig Heart) is a multifunctional enzyme involved in cellular life and death decisions.Cytochrome C is critical in mitochondrial electron transport and intrinsic type II apoptosis.

Celosin K

Celosin K, a triterpenoid saponin isolated from the seeds of Semen Celosiae, is also a potent inhibitor of t-BHP-induced neuronal damage. In addition, Celosin K inhibits oxidative stress, apoptosis, and autophagy.

GLP-2(rat)

GLP-2(rat) is an intestinal growth factor.

Edratide

Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id.

Thrombospondin-1 (1016-1023) (human, bovine, mouse)

Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide.

  Catalog
Abmole Inhibitor Catalog




Keywords: α-Hederin, Hed,alpha-hederin supplier, Apoptosis, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.