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α-Hederin stimulates NO release and is able to upregulate iNOS expression through NF-kappa B transactivation, which may be a mechanism, whereby α-Hederin elicits its biological effects.α-Hederin enhanced some nonenzymatic antioxidant components in liver, which play a partial role in Hed protection against hepatotoxicity produced by some chemicals.treatment of mice with α-Hederin decreases the levels and activities of several P450 enzymes.The suppression of P450 appears to be one of mechanisms by which alpha-hederin protects mice from the hepatotoxicity of some chemicals.It is possible to optimize colorectal cancer cell sensitivity to 5-FU with α-Hederin.
| Molecular Weight | 750.96 |
| Formula | C41H66O12 |
| CAS Number | 27013-91-8 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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