Allopurinol Sodium is a xanthine oxidase inhibitor and a structural isomer of hypoxanthine with an IC50 of 7.82 ± 0.12 μM, which inhibits the conversion of xanthine to uric acid and increases the reuse of hypoxanthine and xanthine in nucleic acid synthesis, thereby reducing serum and urinary uric acid levels, and can be used in gout-related studies.
| Molecular Weight | 159.1 |
| Formula | C5H4N4NaO |
| CAS Number | 17795-21-0 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Eun Kyung Choi, et al. Sodium Nitrite Attenuates Hepatic Ischemia-Reperfusion Injury in Rats
[3] Zeynep Gul, et al. Medical and dietary therapy for kidney stone prevention
[4] Agnes Kiny, et al. Allopurinol-induced hypersensitivity syndrome
| Related Xanthine Oxidase Products |
|---|
| H-Tyr-Phe-OH
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. |
| TEI-6469
TEI-6469 is a xanthine oxidase (XO) inhibitor that may be used in studies related to gout. |
| Phytic acid dodecasodium hydrate
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. |
| Ellagic acid-4-O-beta-D-xylopyranoside
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an 50 of 2.1 μg/mL. |
| Protosappanin A dimethyl acetal
Protosappanin A dimethyl acetal is a homoisoflavonoid. |
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