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ACBI1 is an effective and synergistic PROTAC inhibitor of SMARCA2, SMARCA4 and PBRM1, with DC50 of 6 nM, 11 nM and 32 nM in MV-4-11 cells, respectively. ACBI1 can induce antiproliferative effect and apoptosis.
| Molecular Weight | 936.12 |
| Formula | C49H58FN9O7S |
| CAS Number | 2375564-55-7 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[1] Narendra Bharathy, et al. Oncogene. SMARCA4 biology in alveolar rhabdomyosarcoma
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