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7α,25-Dihydroxycholesterol

Cat. No. M30428

All AbMole products are for research use only, cannot be used for human consumption.

7α,25-Dihydroxycholesterol Structure

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Quality Control & Documentation
Biological Activity

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells.

Chemical Information
Molecular Weight 418.65
Formula C27H46O3
CAS Number 64907-22-8
Form Solid
Solubility (25°C) DMSO 4.55 mg/mL (ultrasonic)
Ethanol 1 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Simona Ceglia, et al. Nat Immunol. An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells

[2] Jae-Sung Kim, et al. Molecules. GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell

[3] William J Griffiths, et al. J Lipid Res. Cholesterol metabolism: from lipidomics to immunology

[4] Jin Huang, et al. J Pharmacol Exp Ther. 7 α,25-Dihydroxycholesterol Suppresses Hepatocellular Steatosis through GPR183/EBI2 in Mouse and Human Hepatocytes

[5] Siquan Sun, et al. Front Pharmacol. 7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases

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Keywords: 7α,25-Dihydroxycholesterol supplier, GPR/FFAR, inhibitors, activators

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