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5,7,8-Trimethoxyflavone

Cat. No. M38981
5,7,8-Trimethoxyflavone Structure
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Biological Activity

5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity.

Chemical Information
Molecular Weight 312.32
Formula C18H16O5
CAS Number 23050-38-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gehad Abdel Wahab et al. RSC Adv. In vitro and in silico studies of SARS-CoV-2 main protease Mpro inhibitors isolated from Helichrysum bracteatum

[2] Luis Apaza Ticona et al. Nat Prod Res. Inhibition of melanin production and tyrosinase activity by flavonoids isolated from Loranthus acutifolius

[3] Qing-Tong Han et al. Zhongguo Zhong Yao Za Zhi. [Studies on flavonoids from Scutellaria moniliorrhiza]

[4] Matsutake Higa et al. Chem Pharm Bull (Tokyo). Isolation of five new flavonoids from Melicope triphylla

[5] T Horie et al. J Med Chem. Syntheses of 5,7,8- and 5,6,7-trioxygenated 3-alkyl-3',4'-dihydroxyflavones and their inhibitory activities against arachidonate 5-lipoxygenase

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Keywords: 5,7,8-Trimethoxyflavone supplier, NO Synthase, inhibitors, activators

 
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