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3-O-Acetyloleanolic acid

Cat. No. M18267
3-O-Acetyloleanolic acid Structure
Size Price Availability Quantity
5mg USD 300  USD300 In stock
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Biological Activity

3-O-Acetyloleanolic acid

Chemical Information
Molecular Weight 498.74
Formula C32H50O4
CAS Number 4339-72-4
Form Solid
Solubility (25°C) DMSO 2 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jeon Hwang-Bo, et al. Phytother Res. 3-O-Acetyloleanolic acid inhibits angiopoietin-1-induced angiogenesis and lymphangiogenesis via suppression of angiopoietin-1/Tie-2 signaling

[2] Jeon Hwang-Bo, et al. BMC Cancer. 3-O-Acetyloleanolic acid inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral cancer sentinel lymph node animal model

[3] Eunyoung Kim, et al. J Pharm Biomed Anal. Simultaneous determination of 3-O-acetyloleanolic acid and oleanolic acid in rat plasma using liquid chromatography coupled to tandem mass spectrometry

[4] En-Ji Cui, et al. Biotechnol Lett. 3-O-Acetyloleanolic acid exhibits anti-angiogenic effects and induces apoptosis in human umbilical vein endothelial cells

[5] Ki Hyun Yoo, et al. Phytother Res. 3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cells

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