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3-O-(2'E,4'Z-Decadienoyl)ingenol

Cat. No. M30679
3-O-(2'E,4'Z-Decadienoyl)ingenol Structure
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Biological Activity

3-O-(2'E,4'Z-Decadienoyl)ingenol is a natural diterpene that exhibits significant anticomplement activity with an IC50 of 89.5 μM.

Chemical Information
Molecular Weight 498.65
Formula C30H42O6
CAS Number 84680-59-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qiao Zhang, et al. J Ethnopharmacol. The water expelling effect evaluation of 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol and ingenol on H22 mouse hepatoma ascites model and their content differences analysis in Euphorbia kansui before and after stir-fried with vinegar by UPLC

[2] Qiao Zhang, et al. Molecules. Toxicity Reduction of Euphorbia kansui Stir-Fried with Vinegar Based on Conversion of 3- O-(2' E,4' Z-Decadi-enoyl)-20- O-acetylingenol

[3] Xin Shu, et al. BMC Complement Altern Med. Ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry analysis of the impact of processing on toxic components of Kansui Radix

[4] Jing Gao, et al. J Ethnopharmacol. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces apoptosis in intestinal epithelial cells of rats via mitochondrial pathway

[5] Li-Yan Wang, et al. J Nat Prod. Diterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus

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Keywords: 3-O-(2'E,4'Z-Decadienoyl)ingenol supplier, Complement System, inhibitors, activators

 
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