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3'-Hydroxypterostilbene

Cat. No. M10997
3'-Hydroxypterostilbene Structure
Size Price Availability Quantity
5mg USD 95  USD95 In stock
10mg USD 160  USD160 In stock
20mg USD 260  USD260 In stock
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Quality Control & Documentation
Biological Activity

3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC for COLO 205, HCT-116 and HT-29 cells) by inducing apoptosis (apoptosis) and autophagy50 9.0, 40.2 and 70.9 μM, respectively).

Chemical Information
Molecular Weight 272.3
Formula C16H16O4
CAS Number 475231-21-1
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pei-Sheng Lee, et al. Phytomedicine. 3'-Hydroxypterostilbene Inhibits 7,12-Dimethylbenz[a]anthracene (DMBA)/12-O-Tetradecanoylphorbol-13-Acetate (TPA)-Induced Mouse Skin Carcinogenesis

[2] Pei-Sheng Lee, et al. J Agric Food Chem. 3'-Hydroxypterostilbene Potently Alleviates Obesity Exacerbated Colitis in Mice

[3] Ching-Shu Lai, et al. J Agric Food Chem. 3'-Hydroxypterostilbene Suppresses Colitis-Associated Tumorigenesis by Inhibition of IL-6/STAT3 Signaling in Mice

[4] Hui-Yun Tsai, et al. J Food Drug Anal. Biological actions and molecular effects of resveratrol, pterostilbene, and 3'-hydroxypterostilbene

[5] Manlio Tolomeo, et al. Int J Biochem Cell Biol. Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells

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