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22-Oxacalcitriol is a non-calcemic vitamin D3 analog and VDR ligand. Suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Exhibits similar effects to calcitriol in osteoblast-like cells. Inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.
| Molecular Weight | 418.61 |
| Formula | C26H42O4 |
| CAS Number | 103909-75-7 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Masahide Mizobuchi, et al. Clinical uses of 22-oxacalcitriol
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