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Cat. No. M6325
22-Oxacalcitriol Structure


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10mg USD 740  USD740 In stock
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Biological Activity

22-Oxacalcitriol is a non-calcemic vitamin D3 analog and VDR ligand. Suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Exhibits similar effects to calcitriol in osteoblast-like cells. Inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.

Chemical Information
Molecular Weight 418.61
Formula C26H42O4
CAS Number 103909-75-7
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Kazunori Inoue, et al. Maxacalcitol (22-Oxacalcitriol (OCT)) Retards Progression of Left Ventricular Hypertrophy with Renal Dysfunction Through Inhibition of Calcineurin-NFAT Activity

[2] Stephanie L Merrigan, et al. Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo

[3] C-N Zhou, et al. 22-oxacalcitriol protects myocardial ischemia-reperfusion injury by suppressing NF-κB/TNF-α pathway

[4] Magda Hamzawy, et al. 22-oxacalcitriol prevents acute kidney injury via inhibition of apoptosis and enhancement of autophagy

[5] Masahide Mizobuchi, et al. Clinical uses of 22-oxacalcitriol

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Keywords: 22-Oxacalcitriol, 22-Oxacalcitriol supplier, Vitamin, inhibitors, activators

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