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1-Methyl-7-nitroisatoic anhydride

Cat. No. M13759
1-Methyl-7-nitroisatoic anhydride Structure
Synonym:

1M7

Size Price Availability Quantity
5mg USD 250  USD250 In stock
10mg USD 375  USD375 In stock
50mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

1-methyl-7-nitroisatoic anhydride (1M7) is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.

Chemical Information
Molecular Weight 222.15
CAS Number 73043-80-8
Solubility (25°C) DMSO 50 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Adam B Fessler, et al. Bioconjug Chem. Innately Water-Soluble Isatoic Anhydrides with Modulated Reactivities for RNA SHAPE Analysis

[2] W-Matthias Leeder, et al. Methods Mol Biol. Mapping the RNA Chaperone Activity of the T. brucei Editosome Using SHAPE Chemical Probing

[3] Steven Busan, et al. Biochemistry. Guidelines for SHAPE Reagent Choice and Detection Strategy for RNA Structure Probing Studies

[4] Greggory M Rice, et al. Methods Enzymol. SHAPE analysis of small RNAs and riboswitches

[5] Rushia Turner, et al. RNA. Safer one-pot synthesis of the 'SHAPE' reagent 1-methyl-7-nitroisatoic anhydride (1m7)

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Keywords: 1-Methyl-7-nitroisatoic anhydride, 1M7 supplier, Fluorescent Dye, inhibitors, activators


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