Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M3539 | Verteporfin (CL 318952) | Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin (CL 318952) is a YAP inhibitor that disrupts YAP-TEAD interactions, and it is also an inhibitor of autophagy. |
| M43572 | IAG933 | IAG933 is a first-in-class, selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor. IAG933 specifically abrogates the interaction between YAP/TAZ coactivators and all four TEAD isoforms, thus selectively inhibiting TEAD-driven transcriptional activity and inducing anti-cancer effects. |
| M43570 | IK-930 | IK-930 is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 µM. |
| M31172 | Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA | Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is an agonist of Protease-Activated Receptor 3 (PAR-3). |
| M31171 | YAP/TAZ inhibitor-2 | YAP/TAZ inhibitor-2 is a potent, orally bioavailable TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM that exhibits anticancer and antiproliferative activity. |
| M29390 | TT-10 | TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss. |
| M21088 | K-975 | K-975 is a potent, selective and orally active TEAD inhibitor that strongly inhibits protein-protein interactions between YAP1/TAZ and TEAD. |
| M21087 | VT103 | VT103, a VT101 analog, is a selective and orally active TEAD1 protein palmitoylation inhibitor that can be used in cancer research. VT103 inhibits the transcription of YAP/TAZ-TEAD promoted gene, blocks the auto-palmitoylation of TEAD, and interferes with the interaction between YAP/TAZ and TEAD. |
| M21084 | GA-017 | GA-017 is a potent and selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2) with IC50 values of 4.10 and 3.92 nM, respectively.GA-017 is a cell proliferation activator.GA-017 promotes YAP/TAZ activation and nuclear translocation.GA-017 promotes cell growth in 3D culture conditions.GA-017 Enhances the formation of mouse intestinal organoid isolates. |
| M21083 | PY-60 | PY-60 is a specific activator (Kd=1.4 µM) of YAP transcriptional activity targeting membrane associated protein A2 (ANXA2).PY-60 binds directly to ANXA2 and antagonizes its normal cellular function of inhibiting YAP activity. |
| M20760 | MYF-01-37 | MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein. |
| M14938 | YAP/TAZ inhibitor-1 | YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor with an IC50 of <0.100 μΜ in firefly luciferase assay. |
| M14937 | TED-347 | TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. |
| M11165 | Super-TDU | Super-TDU is a specific YAP antagonist that targets YAP-TEAD interactions. Super-TDU can inhibit tumor growth in mouse models of gastric cancer. |
| M10224 | YAP-TEAD-IN-1 TFA | YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP-TEAD interaction with IC50 of 25 nM. |
| M57232 | BAY-593 | BAY-593 is an orally active GGTase-I inhibitor. |
| M57231 | SWTX-143 | SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. |
| M50386 | YAP-TEAD-IN-1 | YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). |
| M43571 | Lappaol F | Lappaol F, a lignin, is an anticancer agent. |
| M43569 | YTP-17 | YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. |
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