Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M43570 | IK-930 | IK-930 is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 µM. |
| M31172 | Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA | Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is an agonist of Protease-Activated Receptor 3 (PAR-3). |
| M31171 | YAP/TAZ inhibitor-2 | YAP/TAZ inhibitor-2 is a potent, orally bioavailable TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM that exhibits anticancer and antiproliferative activity. |
| M29390 | TT-10 | TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss. |
| M21088 | K-975 | K-975 is a potent, selective and orally active TEAD inhibitor that strongly inhibits protein-protein interactions between YAP1/TAZ and TEAD. |
| M21087 | VT103 | VT103, a VT101 analog, is a selective and orally active TEAD1 protein palmitoylation inhibitor that can be used in cancer research. VT103 inhibits the transcription of YAP/TAZ-TEAD promoted gene, blocks the auto-palmitoylation of TEAD, and interferes with the interaction between YAP/TAZ and TEAD. |
| M21084 | GA-017 | GA-017 is a potent and selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2) with IC50 values of 4.10 and 3.92 nM, respectively.GA-017 is a cell proliferation activator.GA-017 promotes YAP/TAZ activation and nuclear translocation.GA-017 promotes cell growth in 3D culture conditions.GA-017 Enhances the formation of mouse intestinal organoid isolates. |
| M20760 | MYF-01-37 | MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein. |
| M14938 | YAP/TAZ inhibitor-1 | YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor with an IC50 of <0.100 μΜ in firefly luciferase assay. |
| M14937 | TED-347 | TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. |
| M11165 | Super-TDU | Super-TDU is a specific YAP antagonist that targets YAP-TEAD interactions. Super-TDU can inhibit tumor growth in mouse models of gastric cancer. |
| M10224 | YAP-TEAD-IN-1 TFA | YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP-TEAD interaction with IC50 of 25 nM. |
| M55023 | VT3989 | VT3989 is a first-in-class, orally active, potent and selective YAP/TEAD auto-palmitoylation inhibitor. VT3989 works by inhibiting TEAD palmitoylation, which in turn blocks YAP function. |
| M50386 | YAP-TEAD-IN-1 | YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). |
| M43572 | YAP-TEAD-IN-3 | YAP-TEAD-IN-3 is a YAP/TAZ-TEAD inhibitor. |
| M43571 | Lappaol F | Lappaol F, a lignin, is an anticancer agent. |
| M43569 | YTP-17 | YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. |
| M40561 | GNE-7883 | GNE-7883 is a potent pan-TEAD small molecule inhibitor that inhibits the interaction between YAP/TAZ and TEAD through altered regulation. It possesses antiproliferative and antitumor activity and can be used in tumor-related studies. |
| M31263 | VT02956 | VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and tumor organoids. |
| M31170 | MSC-4106 | MSC-4106 is an orally active inhibitor of the YAP/TAZ-TEAD complex that blocks the auto-palmitoylation of TEAD1 and TEAD3, and can be used for tumor-related studies. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
