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YAP/TAZ inhibitor-2 is a potent, orally bioavailable TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM that exhibits anticancer and antiproliferative activity.
| Molecular Weight | 390.33 |
| Formula | C19H14F4N4O |
| CAS Number | 2762617-31-0 |
| Form | Solid |
| Storage | -20°C |
| Related YAP Products |
|---|
| BAY-593
BAY-593 is an orally active GGTase-I inhibitor. |
| SWTX-143
SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. |
| YAP-TEAD-IN-1
YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). |
| IAG933
IAG933 is a first-in-class, selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor. IAG933 specifically abrogates the interaction between YAP/TAZ coactivators and all four TEAD isoforms, thus selectively inhibiting TEAD-driven transcriptional activity and inducing anti-cancer effects. |
| Lappaol F
Lappaol F, a lignin, is an anticancer agent. |
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