Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M2475 | Bucladesine Sodium Salt | Bucladesine, a membrane permeable selective activator of PKA, has a critical role in up-regulation of ChAT and VAChT gene expression in PC12 cells by activation of extracellular signal regulated kinase (ERK) in Ca2+- and PKA-dependent manner. |
| M50398 | H-Arg-Gly-Tyr-Ala-Leu-Gly-OH | H-Arg-Gly-Tyr-Ala-Leu-Gly-OH is a competitive and CAMP dependent protein kinase inhibitor. |
| M50397 | PKI (5-24), amide | PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. |
| M50396 | PKI(5-22)amide | PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). |
| M50395 | PKA Substrate | PKA Substrate is a potent and selective substrate peptide of PKA that can be used to detect PKA activity. |
| M50394 | Cys-Kemptide | Cys-Kemptide is a cysteine-terminated substrate peptide that can used to measure protein kinase A (PKA) activity. |
| M50393 | PKItide | PKItide exhibits an IC50 of 0.2 μM for cAMP-PK. |
| M49788 | 4′-Demethylnobiletin | 4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signal |
| M43559 | BLU0588 | BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC50 of 1 nM and dissociation constant (Kd) of 4 nM. |
| M42037 | HA-1004 | HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. |
| M30532 | Sp-cAMPS | Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM. |
| M30406 | Balanol | Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides. |
| M28584 | STAD 2 | STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism. |
| M28396 | Sp-cAMPS sodium salt | Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM. |
| M27857 | 8-pCPT-2'-O-Me-cAMP-AM | 8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with PKA pathway. |
| M20312 | WAY-299562 | WAY-299562 is a modulator of the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP). |
| M14907 | Rp-cAMPS sodium salt | Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. |
| M14906 | PKI(5-24) | PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor. |
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