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Bucladesine Sodium Salt

Cat. No. M2475
Bucladesine Sodium Salt Structure

Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 64  USD64 In stock
100mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Bucladesine, a membrane permeable selective activator of PKA, has a critical role in up-regulation of ChAT and VAChT gene expression in PC12 cells by activation of extracellular signal regulated kinase (ERK) in Ca2+- and PKA-dependent manner.

Product Citations
Chemical Information
Molecular Weight 492.38
Formula C18H24N5O8P.Na
CAS Number 16980-89-5
Solubility (25°C) Water ≥ 34 mg/mL
DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Forouz Salehi, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain

[2] Mahshid Sadat Hosseini-Zare, et al. Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice

[3] G Wolf. Release of stored retinol from adipocytes

[4] E Mafune, et al. Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin

[5] F H Epstein, et al. Na-K-Cl cotransport in chloride-transporting epithelia

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Keywords: Bucladesine Sodium Salt, Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP supplier, PKA, inhibitors, activators

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