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Balanol

Cat. No. M30406

All AbMole products are for research use only, cannot be used for human consumption.

Balanol Structure
Synonym:

Ophiocordin; Azepinostatin

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Quality Control & Documentation
Biological Activity

Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides.

Chemical Information
Molecular Weight 550.51
Formula C28H26N2O10
CAS Number 63590-19-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Rui-Qi Li, et al. J Fungi (Basel). Gram-Level Production of Balanol through Regulatory Pathway and Medium Optimization in Herb Fungus Tolypocladium ophioglossoides

[2] Sajjad Ahmad, et al. Curr Org Synth. Comprehensive Account on the Synthesis of (-)-Balanol and its Analogues

[3] Xian He, et al. Org Lett. Revelation of the Balanol Biosynthetic Pathway in Tolypocladium ophioglossoides

[4] Ari Hardianto, et al. BMC Bioinformatics. Exploration of charge states of balanol analogues acting as ATP-competitive inhibitors in kinases

[5] Vineet Pande, et al. Anticancer Agents Med Chem. The Protein kinase inhibitor balanol: structure-activity relationships and structure-based computational studies

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Keywords: Balanol, Ophiocordin; Azepinostatin supplier, PKA, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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