| Cat.No. | Name | Information |
|---|---|---|
| M25328 | Latozinemab | Latozinemab (AL001) is a recombinant humanized anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research. |
| M11312 | AF40431 | AF40431 is the first reported small molecule ligand of sortilin with IC50 of 4.4 µM and Kd of 0.7 µM. AF40431 binds to the neurotensin binding site of sortilin. |
| M10571 | Neurotensin | Neurotensin is a gut tridecapeptide with many central and peripheral functions, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors(NTR). |
| M10171 | JMV 449 acetate | JMV 449 acetate is a potent neurotensin receptor agonist. |
| M10142 | SBI-553 | SBI-553 is a potent and effective, brain-penetrant and allosteric modulator of NTR1 with EC50 of 0.34 μM. |
| M7330 | Meclinertant | Meclinertant (SR 48692) is an effective, selective, non-peptide and oral antagonist of active neurotensin receptor (NTS1). Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization in human colon cancer cells, with a pA2 value of 8.13. Meclinertant has anti-anxiety, anti-addiction and memory disorder effects. |
| M1558 | AF38469 | AF38469 |
| M56287 | SORT-PGRN interaction inhibitor 1 | SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM. |
| M54095 | Kinetensin | Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. |
| M53973 | [Lys8, Lys9]-Neurotensin (8-13) | [Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2. |
| M53004 | [D-Trp11]-Neurotensin | [D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. |
| M53003 | Contulakin G | Contulakin G is an O-glycosylated invertebrate neurotensin. |
| M53002 | Acetyl neurotensin (8-13) | Acetyl neurotensin (8-13) is the shortest analog of neurotensin with full binding and pharmacological activities. |
| M53001 | JMV 449 | JMV 449 is a potent neurotensin receptor agonist. |
| M41883 | BVFP | BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. |
| M41882 | hNTS1R agonist-1 | hNTS1R agonist-1 is a BBB permeable hNTS1R full agonist (Ki: 6.9 nM) . |
| M41881 | SORT-PGRN interaction inhibitor 3 | SORT-PGRN interaction inhibitor 3 is a SORT-PGRN interaction inhibitor (IC50: 0.17 μM). |
| M30352 | Neurotensin(8-13) | Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. |
| M21376 | ML314 | ML314 is an NTR1 agonist with an EC50 of 1.9 μM, weakly inhibits NTR2 and GPR35, and fails to stimulate calcium ion transfer. |
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