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Neurotensin Receptor Neurotensin Receptor (NTR)

Cat.No.  Name Information
M11312 AF40431 AF40431 is the first reported small molecule ligand of sortilin with IC50 of 4.4 µM and Kd of 0.7 µM. AF40431 binds to the neurotensin binding site of sortilin.
M10571 Neurotensin Neurotensin is a gut tridecapeptide with many central and peripheral functions, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors(NTR).
M10171 JMV 449 acetate JMV 449 acetate is a potent neurotensin receptor agonist.
M10142 SBI-553 SBI-553 is a potent and effective, brain-penetrant and allosteric modulator of NTR1 with EC50 of 0.34 μM.
M7330 Meclinertant Meclinertant (SR 48692) is an effective, selective, non-peptide and oral antagonist of active neurotensin receptor (NTS1). Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization in human colon cancer cells, with a pA2 value of 8.13. Meclinertant has anti-anxiety, anti-addiction and memory disorder effects.
M1558 AF38469 AF38469
M54095 Kinetensin Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
M53973 [Lys8, Lys9]-Neurotensin (8-13) [Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2.
M53004 [D-Trp11]-Neurotensin [D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips.
M53003 Contulakin G Contulakin G is an O-glycosylated invertebrate neurotensin.
M53002 Acetyl neurotensin (8-13) Acetyl neurotensin (8-13) is the shortest analog of neurotensin with full binding and pharmacological activities.
M53001 JMV 449 JMV 449 is a potent neurotensin receptor agonist.
M41883 BVFP BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM.
M41882 hNTS1R agonist-1 hNTS1R agonist-1 is a BBB permeable hNTS1R full agonist (Ki: 6.9 nM) .
M41881 SORT-PGRN interaction inhibitor 3 SORT-PGRN interaction inhibitor 3 is a SORT-PGRN interaction inhibitor (IC50: 0.17 μM).
M30352 Neurotensin(8-13) Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
M25328 Latozinemab Latozinemab (AL001) is a recombinant humanized anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research.
M21376 ML314 ML314 is an NTR1 agonist with an EC50 of 1.9 μM, weakly inhibits NTR2 and GPR35, and fails to stimulate calcium ion transfer.

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