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JMV 449 acetate is a potent neurotensin receptor agonist (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.
| Molecular Weight | 807.03 |
| Formula | C40H70N8O9 |
| CAS Number | 139026-66-7 (free base) |
| Solubility (25°C) | Water 90 mg/mL |
| Storage | -20°C, sealed |
| Related Neurotensin Receptor Products |
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| SORT-PGRN interaction inhibitor 1
SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM. |
| Kinetensin
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. |
| [Lys8, Lys9]-Neurotensin (8-13)
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2. |
| [D-Trp11]-Neurotensin
[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. |
| Contulakin G
Contulakin G is an O-glycosylated invertebrate neurotensin. |
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