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Kinesin Kinesin

Cat.No.  Name Information
M1786 Ispinesib Ispinesib (SB 715992) is the first potent, highly specific small-molecule inhibitor of kinesin spindle protein (KSP) with an IC50 of 4.1 nM.
M55321 Filanesib hydrochloride Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro.
M10666 CW069 CW069 is an allosteric inhibitor of HSET with IC50 of 75 μM, it showed marked activity against HSET in vitro.
M9174 ARQ 621 ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.
M8930 EMD534085 EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
M8918 BAY 1217389 BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
M7876 K-858 Eg5 is a key protein involved in the formation of bipolar spindles.
M6674 Dimethylenastron Dimethylenastron is a inhibitor of mitotic motor kinesin Eg5.
M5230 Monastrol Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.
M3672 AZD4877 AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity.
M3216 ARRY-520 ARRY-520 is a potent and selective kinesin spindle protein (KSP) inhibitor with an IC50 of 15 nM for A2780, CP70 and 01-28 cell lines in vitro.
M2868 MPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.
M2171 GSK923295 GSK923295 is an allosteric inhibitor of CENP-E with Ki value of 3.2 nM.
M2128 AZ3146 AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor with IC50 of 35 nM.
M1983 SB-743921 SB-743921 is a highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5).
M41518 Eg5-IN-1 Eg5-IN-1 is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM.
M40715 PVZB-1194 PVZB-1194 is a biphenyl-type inhibitor of kinesin Eg5 that induces apoptosis by inhibiting Eg5 ATPase activity and shows potent kinesin spindle protein (KSP) inhibition only in the presence of microtubules, with anticancer activity.
M30868 Litronesib Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.
M30678 MK-0731  MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy.
M29911 BRD9876  BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research.




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