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ARQ 621

Cat. No. M9174
ARQ 621 Structure
Size Price Availability
5mg USD 195  USD195 4-7 Days
25mg USD 495  USD495 4-7 Days
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Quality Control & Documentation
Biological Activity

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.

Chemical Information
Molecular Weight 552
Formula C28H24Cl2FN5O2
CAS Number 1095253-39-6
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Renato Antunes Schiave Germano, et al. Comparison of the hypotensor effect between latanoprost versus selective laser trabeculoplasty obtained with the water drinking test

[2] Rubens Paulo Arajo Salomo, et al. A diagnostic approach for neurodegeneration with brain iron accumulation: clinical features, genetics and brain imaging

[3] Ana Cristina Viana da Silva, et al. Esophageal motility in troublesome belching

[4] A Tomillero, et al. Gateways to clinical trials

[5] Jos Gilberto H Vieira, et al. Evolution of PTH assays

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Keywords: ARQ 621 supplier, Kinesin, inhibitors, activators

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