About 17 results found for searched term "Kinesin" (0.136 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1786 | Ispinesib | Kinesin |
| SB-715992, CK0238273 | ||
| Ispinesib (SB 715992) is the first potent, highly specific small-molecule inhibitor of kinesin spindle protein (KSP) with an IC50 of 4.1 nM. | ||
| M3216 | ARRY-520 | Kinesin |
| Filanesib | ||
| ARRY-520 is a potent and selective kinesin spindle protein (KSP) inhibitor with an IC50 of 15 nM for A2780, CP70 and 01-28 cell lines in vitro. | ||
| M3672 | AZD4877 | Kinesin |
| AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. | ||
| M5230 | Monastrol | Kinesin |
| CAS# 254753-54-3 | ||
| Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles. | ||
| M6674 | Dimethylenastron | Kinesin |
| Dimethylenastron is a inhibitor of mitotic motor kinesin Eg5. | ||
| M7876 | K-858 | Kinesin |
| K858 Racemic | ||
| K858 (Racemic) is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM. Eg5 is a key protein involved in the formation of bipolar spindles. | ||
| M8930 | EMD534085 | Kinesin |
| EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM. | ||
| M13687 | AZ82 | Kinesin |
| AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. | ||
| M22468 | Sovilnesib (AMG 650) | Microtubule |
| AMG 650 | ||
| Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM. | ||
| M29911 | BRD9876 | Kinesin |
| BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research. | ||
| M30678 | MK-0731 | Kinesin |
| MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy. | ||
| M30868 | Litronesib | Kinesin |
| LY2523355 | ||
| Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity. | ||
| M40715 | PVZB-1194 | Kinesin |
| PVZB-1194 is a biphenyl-type inhibitor of kinesin Eg5 that induces apoptosis by inhibiting Eg5 ATPase activity and shows potent kinesin spindle protein (KSP) inhibition only in the presence of microtubules, with anticancer activity. | ||
| M41518 | Eg5-IN-1 | Kinesin |
| Eg5-IN-1 is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM. | ||
| M55321 | Filanesib hydrochloride | Kinesin |
| ARRY-520 hydrochloride | ||
| Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. | ||
| M55997 | AZD4877 | Kinesin |
| AZD4877 is another isostere to Ispinesiband also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. | ||
| M55996 | Filanesib TFA | Kinesin |
| Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. | ||
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