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 About 13 results found for searched term "Kinesin" (0.16 seconds)

Cat.No.  Name Target
M1786 Ispinesib Kinesin
SB-715992, CK0238273
Ispinesib (SB 715992) is the first potent, highly specific small-molecule inhibitor of kinesin spindle protein (KSP) with an IC50 of 4.1 nM.
M3216 ARRY-520 Kinesin
Filanesib
ARRY-520 is a potent and selective kinesin spindle protein (KSP) inhibitor with an IC50 of 15 nM for A2780, CP70 and 01-28 cell lines in vitro.
M3672 AZD4877 Kinesin
AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity.
M5230 Monastrol Kinesin
CAS# 254753-54-3
Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.
M6674 Dimethylenastron Kinesin
Dimethylenastron is a inhibitor of mitotic motor kinesin Eg5.
M8930 EMD534085 Kinesin
EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
M13687 AZ82 Kinesin
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.
M22468 Sovilnesib (AMG 650) Microtubule
AMG 650
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM.
M29911 BRD9876  Kinesin
BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research.
M30678 MK-0731  Kinesin
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy.
M30868 Litronesib Kinesin
LY2523355
Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.
M40715 PVZB-1194 Kinesin
PVZB-1194 is a biphenyl-type inhibitor of kinesin Eg5 that induces apoptosis by inhibiting Eg5 ATPase activity and shows potent kinesin spindle protein (KSP) inhibition only in the presence of microtubules, with anticancer activity.
M41518 Eg5-IN-1 Kinesin
Eg5-IN-1 is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM.



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