Galectin Galectin

Inhibitors

Cat.No.	Name	Information
M22469	G3-C12	G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
M14088	OTX008	OTX008 is a selective inhibitor of galectin-1.
M9897	GB1107	GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.
M9324	TD139	TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain (Kd = 14 nM).