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Cat. No. M14088
OTX008 Structure

Calixarene 0118; PTX008

Size Price Availability
5mg USD 190  USD190 4-7 Days
10mg USD 290  USD290 4-7 Days
25mg USD 590  USD590 4-7 Days
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Quality Control & Documentation
Biological Activity

OTX008 is a selective inhibitor of galectin-1.

Chemical Information
Molecular Weight 937.18
CAS Number 286936-40-1
Solubility (25°C) Ethanol ≥ 33.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Laetitia Gheysen, et al. New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer

[2] Ahmed M Abu El-Asrar, et al. Galectin-1 studies in proliferative diabetic retinopathy

[3] Nathan A Koonce, et al. Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models

[4] Lucile Astorgues-Xerri, et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

[5] Massimo Zucchetti, et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib

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Abmole Inhibitor Catalog

Keywords: OTX008, Calixarene 0118; PTX008 supplier, Galectin, inhibitors, activators

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