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G3-C12

Cat. No. M22469
G3-C12 Structure
Size Price Availability Quantity
5mg USD 215  USD215 In stock
10mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer.


Sequence:  Ala-Asn-Thr-Pro-Cys-Gly-Pro-Tyr-Thr-His-Asp-Cys-Pro-Val-Lys-Arg

Chemical Information
Molecular Weight 1758.98
Formula C74H115N23O23S2
CAS Number 848301-94-0
Solubility (25°C) Water 100 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xia Yuan, et al. Int J Pharm. Development of (G3-C12)-mediated camptothecin polymeric prodrug targeting to Galectin-3 receptor against androgen-independent prostate cancer

[2] Wei Sun, et al. Mol Pharm. G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment

[3] Yang Yang, et al. Mol Pharm. Targeting prostate carcinoma by G3-C12 peptide conjugated N-(2-hydroxypropyl)methacrylamide copolymers

[4] Yang Yang, et al. Biomaterials. Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates

[5] Kam Leung. 111In-Tetraazacyclododecane- N, N’, N’’, N’’’-tetraacetic acid-(GSG)-ANTPCGPYTHDCPVKR

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Keywords: G3-C12 supplier, Galectin, inhibitors, activators


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