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GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.
Molecular Weight | 522.32 |
Formula | C20H16Cl2F3N3O4S |
CAS Number | 1978336-61-6 |
Solubility (25°C) | DMSO 45 mg/mL |
Storage | -20°C, dry, sealed |
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