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Cat. No. M9897
GB1107 Structure


Size Price Availability Quantity
10mM*1mL in DMSO USD 340  USD340 In stock
5mg USD 295  USD295 In stock
10mg USD 470  USD470 In stock
25mg USD 1000  USD1000 In stock
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Quality Control & Documentation
Biological Activity

GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.

Chemical Information
Molecular Weight 522.32
Formula C20H16Cl2F3N3O4S
CAS Number 1978336-61-6
Solubility (25°C) DMSO 45 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Lynda Vuong, et al. Cancer Res. An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade

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Abmole Inhibitor Catalog

Keywords: GB1107, GB-1107 supplier, Galectin, inhibitors, activators

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