| Cat.No. | Name | Information |
|---|---|---|
| M1885 | Tipifarnib | Tipifarnib (IND 58359) inhibited Farnesitransferase (FTase) with an IC50 of 0.86 nM. Tipifarnib has potential antitumor activity. Tipifarnib can inhibit exosome release of tumor cells. |
| M28936 | YM-53601 hydrochloride | YM-53601 hydrochloride is a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 hydrochloride inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. YM-53601 hydrochloride is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. |
| M27907 | CP-609754 | CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL. |
| M25466 | Manumycin A | Manumycin A is a selective, competitive inhibitor of protein farnesyl transferase (FTase) with respect to farnesylpyrophosphate (Ki=1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A is also an antibiotic. |
| M11225 | FTI-277 hydrochloride | Fti-277 Hydrochloride, an FTase inhibitor of Farnici transferase, is a highly effective Ras CAAX peptide analog that inhibits H-RAS and K-RAS signal transduction. Fti-277 hydrochloride inhibits hepatitis delta virus (HDV) infection. |
| M5024 | L-778123 hydrochloride | L-778123 hydrochloride is a dual inhibitor of FPTase and GGptase-I with IC50 values of 2 nM and 98 nM, respectively. |
| M3840 | Tipifarnib S enantiomer | Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib, Tipifarnib S enantiomer is the less active isomer. |
| M2804 | LB42708 | LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively. |
| M42399 | L-778123 | L-778123 is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. |
| M39139 | Andrastin A | Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species. |
| M30111 | ABT-100 | ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. |
| M29771 | FGTI-2734 mesylate | FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. |
| M28935 | YM-53601 | YM-53601 is a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. |
| M28036 | FGTI-2734 | FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. |
| M21382 | FTI-2153 | FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase) with an IC50 of 1.4 nM. FTI-2153 effectively inhibits the processing modification of H-Ras protein with an IC50 value of 10 nM, and its inhibitory activity is more than 3000 times that of the processing of Rap1A protein. |
| M7661 | BMS-214662 hydrochloride | BMS-214662 is an orally available, potent and selective inhibitor of farnesyltransferase that reduces Ras prenylation in NF90-8 and ST88-14 sheath tumor (MPNST) cell lines. |
| M7631 | B581 | B581 is a membrane permeable inhibitor of farnesyltransferase. |
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