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FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.
| Molecular Weight | 510.63 |
| Formula | C26H31FN6O2S |
| CAS Number | 1247018-19-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic) |
| Storage | 4°C, sealed |
| Related Farnesyl Transferase Products |
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| FGTI-2734 mesylate
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