Certificate of Analysis
| Product Name: | FGTI-2734 |
| Catalog Number: | M28036 |
| CAS Number: | 1247018-19-4 |
Physical and Chemical Properties
| Formula: | C26H31FN6O2S |
| Molecular Weight: | 510.63 |
| Form: | Solid |
| Solubility: | DMSO 50 mg/mL (ultrasonic) |
| Storage: | 4°C, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |