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Manumycin A is a selective, competitive inhibitor of protein farnesyl transferase (FTase) with respect to farnesylpyrophosphate (Ki=1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein.
Manumycin A is also an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity.
Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling.
Manumycin A is a nSMase inhibitor with EC50 of 0.25 μM.
| Molecular Weight | 550.64 |
| Formula | C31H38N2O7 |
| CAS Number | 52665-74-4 |
| Solubility (25°C) | DMSO |
| Storage | -20°C, dry, sealed |
| Related Farnesyl Transferase Products |
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| L-778123
L-778123 is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. |
| Andrastin A
Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species. |
| ABT-100
ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. |
| FGTI-2734 mesylate
FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. |
| YM-53601 hydrochloride
YM-53601 hydrochloride is a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 hydrochloride inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. YM-53601 hydrochloride is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. |
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