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BACE Beta-site APP cleaving enzyme

Inhibitors

Cat.No.  Name Information
M20868 Phytic acid dipotassium salt Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.

M13414 PF-06751979 PF-06751979 is a potent, brain permeable inhibitor of β -amyloid precursor protein lyase 1 (BACE1) with an IC50 of 7.3 nM.
M10070 LX2343 LX2343 is a BACE1 enzyme inhibitor with IC50 value of 11.43±0.36 μM, and it is a neuroprotective agent.
M9386 Verubecestat (MK-8931) Verubecestat (MK-8931) is a beta-secretase 1 (BACE1) inhibitor.
M5245 Olodaterol The novel once-daily long-acting β2-agonist (LABA) olodaterol is a highly selective and nearly full β2 agonist that provides 24-h bronchodilation in patients with COPD.
M5227 AZD3293 AZD3293, also known as LY3314814 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
M1987 LY2886721 LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease.



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