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Beta-secretase Inhibitor IV is a potent cell-penetrating inhibitor that binds to the active site of BACE-1 and blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for HEK293-APPNFEV cells sAPP_NF). The IC50 of BACE-2, cathepsin D and renin were 230 nM, 7.6 μM and >50 μM, respectively.
| Molecular Weight | 578.72 |
| Formula | C31H38N4O5S |
| CAS Number | 797035-11-1 |
| Solubility (25°C) | DMSO: 100 mg/mL |
| Storage | 2-8℃, protect from light, dry, sealed |
[3] Ramn Cacabelos, et al. CNS Neurol Disord Drug Targets. Novel Therapeutic Strategies for Dementia
[4] Giuseppe Grasso. Mass Spectrom Rev. The use of mass spectrometry to study amyloid-β peptides
| Related BACE Products |
|---|
| AZ-4217
AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. |
| Se-Methylselenocysteine hydrochloride
Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. |
| Glabrolide
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor. |
| Kushenol C
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM. |
| Deoxyneocryptotanshinone
Deoxyneocryptotanshinone is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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