About 13 results found for searched term "BACE" (0.051 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4708 | Herbacetin | Others |
| Herbacetin is a natural flavonoid found in flaxseed and has a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor that binds directly to Asp44, Asp243 and Glu384 on ODC. It is also an SGK1 inhibitor. | ||
| M19410 | Fabacein | Others |
| Fabacein | ||
| M21443 | β-Secretase Inhibitor IV | BACE |
| BACE Inhibitor C3 | ||
| β-Secretase Inhibitor IV is a cellular permeability inhibitor that binds to the active site of BACE-1 and blocks its proteolytic activity (IC₅₀= 15 nM in human BACE-1). | ||
| M25259 | Briobacept | Others |
| BR 3FC | ||
| Briobacept (BR 3FC) is a selective human monoclonal antibody targeting to BLyS (BAFF), induces B cells apoptosis. Briobacept is a recombinant glucoprotein, consists of 2 molecules from the BLyS receptor (BR3)and a Fc domain of human IgG1. Briobacept can be used in studies of rheumatoid arthritis (RA). | ||
| M28152 | BACE1-IN-1 | Gamma-secretase/Beta-secretase |
| BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. | ||
| M42634 | BACE1-IN-13 | Gamma-secretase/Beta-secretase |
| BACE1-IN-13 is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. | ||
| M42638 | hAChE/hBACE-1-IN-2 | AChR/AChE |
| hAChE/hBACE-1-IN-2 is a potent, orally active, blood-brain barrier transboundary triple inhibitor of hAChE, hBChE, and HACE-1 with IC50s of 0.113 μM, 1.48 μM and 0.38 μM, respectively. | ||
| M42649 | hAChE/hBACE-1-IN-1 | AChR/AChE |
| hAChE/hBACE-1-IN-1 is an orally active inhibitor of hAChE with blood-brain permeability. | ||
| M44875 | Herbacetin 3-sophoroside-8-glucoside | Others |
| Herbacetin-3-sophoroside-8--glucoside is a natural product that can be isolated from Equisetum hyemale. | ||
| M49733 | AChE/BACE1/GSK3β-IN-1 | Gamma-secretase/Beta-secretase |
| AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. | ||
| M51557 | BACE1 (485-501) | Others |
| BACE1 (485-501) is the carboxyl terminal of BACE1 (Beta-site APP cleaving enzyme 1). | ||
| M52425 | BACE1-IN-10 | Gamma-secretase/Beta-secretase |
| BACE1-IN-10 is a potent BACE1 Inhibitor. | ||
| M52533 | Baceridin | Proteasome |
| Baceridin is a proteasome inhibitor and a cyclic hexapeptide. | ||
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