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hAChE/hBACE-1-IN-2

Cat. No. M42638

All AbMole products are for research use only, cannot be used for human consumption.

hAChE/hBACE-1-IN-2 Structure

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Biological Activity

hAChE/hBACE-1-IN-2 is a potent, orally active, blood-brain barrier transboundary triple inhibitor of hAChE, hBChE, and HACE-1 with IC50s of 0.113 μM, 1.48 μM and 0.38 μM, respectively.

Chemical Information
Molecular Weight 408.52
Formula C22H24N4O2S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] V Surya Prakash et al. Saudi J Biol Sci. In silico analysis of selected nutrition rich fruit of Bunch berry ( Lantana camara) constituents as human acetylcholinesterase (hAchE), carbonic anhydrase II (hCA-II) and carboxylesterase 1 (hCES-1) inhibitory agents

[2] Digambar Kumar Waiker et al. ACS Omega. Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat Alzheimer's Disease

[3] Sakineh Mozaffarnia et al. Eur J Med Chem. Design, synthesis and biological evaluation of 2,3-dihydro-5,6-dimethoxy-1H-inden-1-one and piperazinium salt hybrid derivatives as hAChE and hBuChE enzyme inhibitors

[4] Hitendra N Karade et al. Bioorg Med Chem. Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE)

[5] Adi Goldenzweig et al. Mol Cell. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

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Keywords: hAChE/hBACE-1-IN-2 supplier, AChR/AChE, inhibitors, activators

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