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hAChE/hBACE-1-IN-1

Cat. No. M42649
hAChE/hBACE-1-IN-1 Structure
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Biological Activity

hAChE/hBACE-1-IN-1 is an orally active inhibitor of hAChE with blood-brain permeability.

Chemical Information
Molecular Weight 433.53
Formula C23H23N5O2S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] V Surya Prakash et al. Saudi J Biol Sci. In silico analysis of selected nutrition rich fruit of Bunch berry ( Lantana camara) constituents as human acetylcholinesterase (hAchE), carbonic anhydrase II (hCA-II) and carboxylesterase 1 (hCES-1) inhibitory agents

[2] Digambar Kumar Waiker et al. ACS Omega. Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat Alzheimer's Disease

[3] Donald K Blumenthal et al. J Biol Chem. Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects

[4] Adi Goldenzweig et al. Mol Cell. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

[5] Aditya Kapil Valiveti et al. Chem Biol Interact. Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE)

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Keywords: hAChE/hBACE-1-IN-1 supplier, AChR/AChE, inhibitors, activators


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