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PF-06751979

Cat. No. M13414

All AbMole products are for research use only, cannot be used for human consumption.

PF-06751979  Structure

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Quality Control & Documentation
Biological Activity

PF-06751979 is a potent, brain permeable inhibitor of β -amyloid precursor protein lyase 1 (BACE1) with an IC50 of 7.3 nM.

Chemical Information
Molecular Weight 455.5
Formula C18H19F2N5O3S2
CAS Number 1818339-66-0
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Alvaro Miranda, et al. J Alzheimers Dis. Selective Secretase Targeting for Alzheimer's Disease Therapy

[2] Ruolun Qiu, et al. J Alzheimers Dis. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects

[3] Brian T O'Neill, et al. J Med Chem. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

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  Catalog
Abmole Inhibitor Catalog




Keywords: PF-06751979 supplier, BACE, inhibitors, activators

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