About 9 results found for searched term "X-165" (0.115 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6804 | IBMX | PDE |
| IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964; 3-isobutyl-1-methylxanthine | ||
| IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. | ||
| M21263 | X-165 | Others |
| X-165 is a clinical candidate compound for the study of autologous cell inhibitors in idiopathic pulmonary fibrosis, which was discovered through a 3-cycle DEL screen of 225M compounds obtained from amide coupling. | ||
| M54710 | Senexin B | CDK |
| SNX2-1-165; BCD-115 | ||
| Senexin B is a potent, orally active CDK8/19 inhibitor with Kd values of 140 nM and 80 nM for CDK8 and CDK19, respectively. | ||
| M20833 | Vodobatinib (K0706) | Src-bcr-Abl |
| SCO-088, SUN K706, SUN-K0706 | ||
| Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively. | ||
| M27754 | V116517 | TRP Channel |
| V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM for acid). V116517 can be used for the research of pain. | ||
| M28052 | GKT136901 hydrochloride | NADPH Oxidase |
| GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity. | ||
| M30971 | GKT136901 | NADPH Oxidase |
| GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity. | ||
| M42216 | P2X3 antagonist 38 | P2 Receptor |
| P2X3 antagonist 38 is a potent and orally active P2X3 antagonist with IC50 values of 0.132, 0.165, 0.421 µM for hP2X3, rP2X3, gpP2X3, respectively. | ||
| M42319 | DGKα-IN-6 | DGK |
| DGKα-IN-6 is a DGKα inhibitor with the IC50 of 1.377 nM, extracted from patent WO2022271650 (compound 143). | ||
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