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X-165

Cat. No. M21263
X-165 Structure
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Biological Activity

X-165 is a clinical candidate compound for the study of autologous cell inhibitors in idiopathic pulmonary fibrosis, which was discovered through a 3-cycle DEL screen of 225M compounds obtained from amide coupling.

Chemical Information
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Edyta Rekiel, et al. Molecules. Wetting Properties of Rhamnolipid and Surfactin Mixtures with Triton X-165

[2] Edyta Rekiel, et al. Molecules. Thermodynamic Analysis of the Adsorption and Micellization Activity of the Mixtures of Rhamnolipid and Surfactin with Triton X-165

[3] Atanu Mahata, et al. J Colloid Interface Sci. Studies of Triton X-165-beta-cyclodextrin interactions using both extrinsic and intrinsic fluorescence

[4] Anna Zdziennicka. Langmuir. Surface behavior of Triton X-165 and short chain alcohol mixtures

[5] Manoj Kumbhakar, et al. J Chem Phys. Solvation dynamics in triton-X-100 and triton-X-165 micelles: effect of micellar size and hydration

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