About 5 results found for searched term "Torin 2" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2022 | Torin 2 | mTOR |
| Torin 2 is a potent and selective mTOR inhibitor with IC50 of 2.1 nM. Torin 2 also inhibits DNA-PK with an IC50 of 0.5 nM in the cell free assay. Torin 2 can suppress both mTORC1 and mTORC2. | ||
| M2276 | Torin 1 | mTOR |
| Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively. Torin 1 induces cellular autophagy. | ||
| M4390 | Imperatorin | NO Synthase |
| Ammidin | ||
| Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM. | ||
| M8666 | Urolithin A | ERK |
| Urolithin A is a naturally occurring compound produced by the metabolism in the body of vegetable tannins (ellagic acid and ellagitannins) found in food. It is also a mitochondrial modulator, regulating mitochondrial function in hematopoietic stem cells, as well as restoring blood regeneration in aging hematopoietic stem cells. In addition, Urolithin A is a ligand for the Aromatic Hydrocarbon Receptor (AhR), which promotes the anti-tumor function of CD8+ cytotoxic T-lymphocytes (CTLs) in an AhR-independent manner. Moreover, Urolithin A directly binds to ERK1/2 kinase, enhances its activation, and subsequently phosphorylates and activates the autophagy initiation factor ULK1, thereby promoting autophagy. | ||
| M10595 | MLi-2 | LRRK2 |
| MLi2 | ||
| MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM). | ||
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