About 31 results found for searched term "Sigma Receptor" (0.101 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14060 | CT1812 | Sigma Receptor |
| Sigma-2 receptor antagonist 1 | ||
| CT1812 (Sigma-2 receptor antagonist 1) is an orally active and brain penetrant sigma-2 (σ-2) receptor antagonist with a Ki of 8.5 nM. | ||
| M28755 | Sigma-1 receptor antagonist 1 | Sigma Receptor |
| Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain. | ||
| M42693 | Sigma-1 receptor antagonist 4 | Sigma Receptor |
| Sigma-1 receptor antagonist 4 is a potent σ1R antagonist that significantly enhances the analgesic effect of morphine and rescues morphine-induced analgesic tolerance. | ||
| M42704 | Sigma-1 receptor antagonist 5 | Sigma Receptor |
| Sigma-1 receptor antagonist 5 and histamine H3 (hH3R, Ki=7.7 nM, IC50=215 nM). | ||
| M2593 | Siramesine hydrochloride | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. | ||
| M2388 | Amitriptyline hydrochloride | 5-HT Receptor |
| Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively. | ||
| M2592 | Siramesine | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. | ||
| M2596 | S1RA | Sigma Receptor |
| E-52862 | ||
| S1RA (E-52862) is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM), which showes good selectivity against σ2R (Ki > 1000 nM). | ||
| M2924 | Pentoxyverine Citrate | Sigma Receptor |
| Carbetapentane Citrate | ||
| Pentoxyverine citrate is an orally active sigma-1 receptor agonist with Ki values of 41 nM for σ1, 894 nM for σ2, and 75 nM for σ1 in guinea pig brain membranes.Pentoxyverine citrate is also a muscarinic antagonist. | ||
| M2991 | Cutamesine dihydrochloride | Sigma Receptor |
| AGY94806 dihydrochloride; SA 4503 dihydrochloride | ||
| Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a novel and selective opioid sigma1 receptor agonist with IC50 of 17.4 nM. | ||
| M6203 | Blarcamesine hydrochloride | Sigma Receptor |
| AE-37 hydrochloride; AVex-73 hydrochloride; Anavex 2-73 hydrochloride | ||
| Blarcamesine hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. | ||
| M7669 | BMY-14802 | Sigma Receptor |
| BMY-14802 is a potent and selective sigma-1 (σ1) receptor antagonist with an IC50 value of approximately 100 nM. | ||
| M7903 | Metaphit methanesulfonate salt | Sigma Receptor |
| Metaphit methanesulfonate salt is an irreversible, non-competitive antagonist at the phencyclidine site on the NMDA receptor; sigma receptor irreversible, competitive antagonist. | ||
| M8955 | MIN-101 | 5-HT Receptor |
| Roluperidone; CYR-101 | ||
| MIN-101 (Roluperidone) is a novel compound with affinities for 5-HT2A and sigma-2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively. | ||
| M10721 | Dimemorfan phosphate | Sigma Receptor |
| Dimemorfan phosphate is a potent agonist of sigma 1 receptor that is effective in suppressing cough. | ||
| M10722 | PRE-084 hydrochloride | Sigma Receptor |
| PRE-084 hydrochloride is a highly affinity selective σ1 agonist with an IC50 value of 44 nM in the sigma receptor detection. | ||
| M10723 | Ditolylguanidine | Sigma Receptor |
| 1,3-Di-o-tolylguanidine | ||
| Ditolylguanidine (1,3-Di-o-tolylguanidine) is a sigma receptor (σ1/σ2 receptor) agonist. | ||
| M10724 | Pridopidine | Dopamine Receptor |
| ACR16; ASP2314; FR310826 | ||
| Pridopidine is a dopamine (DA) stabilizer that acts as a low-affinity dopamine D2 receptor (D2R) antagonist. Pridopidine high affinity acts on sigma 1 receptor (S1R),Ki Values of 70 to 80 nM are approximately 100 times higher than their affinity for D2R. | ||
| M10768 | SKF83959 | Others |
| SKF83959 is a potent selective dopamine D1-like Receptor partial agonist. SKF83959 Ki to rats D1，D5，D2AND D3 The values are 1.18, 7.56, 920, and 399 nM, respectively. SKF83959 is a potent sigma (σ)-1 receptor allosteric modulator. SKF83959 belongs to the benzazepine family and has an improving effect on cognitive dysfunction. SKF83959 can be used to study Alzheimer's disease and depression. | ||
| M20793 | Amitriptyline | Serotonin Transporter |
| MK-230; N-750; Ro41575 | ||
| Amitriptyline (MK-230, N-750, Ro41575) is an inhibitor of the serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki values of 3.45 nM and 13.3 nM, respectively, and also inhibits the histamine receptor H1, the histamine receptor H4, 5-HT2, and the Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. It can also inhibit histamine receptor H1, histamine receptor H4, 5-HT2 and Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively, and can be used in studies of depression and neuropathic pain. | ||
| M21001 | Glycerol phenylbutyrate | Others |
| GT4P, HPN-100M, Ravicti | ||
| Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract. | ||
| M22051 | Cutamesine | Sigma Receptor |
| SA4503; AGY 94806 | ||
| Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist, with IC50 of 17.4 nM for the sigma 1 receptor. | ||
| M27813 | CM398 | Sigma Receptor |
| CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice. | ||
| M27937 | σ1 Receptor antagonist-1 | Sigma Receptor |
| σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells. | ||
| M28096 | S1RA hydrochloride | Sigma Receptor |
| E-52862 hydrochloride | ||
| S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization. | ||
| M28136 | E1R | Sigma Receptor |
| E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity. | ||
| M28534 | NE-100 hydrochloride | Sigma Receptor |
| NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death. | ||
| M28581 | PD 144418 | Sigma Receptor |
| PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity. | ||
| M28864 | PD 144418 oxalate | Sigma Receptor |
| PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 oxalate shows potential antipsychotic activity. | ||
| M42694 | KSK68 | Sigma Receptor |
| KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. | ||
| M42695 | KSK67 | Sigma Receptor |
| KSK67 is a high-affinity dual sigma-2 and histamine H3 receptor antagonist, with Kis of 3.2, 1531, 101 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. | ||
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