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Sigma-1 receptor antagonist 4 is a potent σ1R antagonist that significantly enhances the analgesic effect of morphine and rescues morphine-induced analgesic tolerance.
| Molecular Weight | 334.45 |
| Formula | C22H26N2O |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Manuel Merlos et al. Handb Exp Pharmacol. Sigma-1 Receptor and Pain
[4] Xiao-Fei Gao et al. PLoS One. Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels
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