About 17 results found for searched term "SIS17" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1458 | SIS17 | HDAC |
| SIS17 is a histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. | ||
| M5927 | Retinoic acid | PPAR |
| ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid | ||
| Retinoic acid is A metabolite of vitamin A and plays an important role in cell growth, differentiation and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors with an IC50 of 14 nM for RARα/β/γ. The Kd value of Retinoic acid combined with PPARβ/δ is 17 nM. Retinoic acid inhibits the transcription factor Nrf2 by activating Retinoic acid receptors. | ||
| M11492 | Recombinant Human Endostatin (P. pastoris) | Recombinant Proteins |
| Endostatin | ||
| Recombinant human Endostatin protein (P. pastoris) is determined by the formation of endothelial cells. Endostatin concentration of 10 μg/ mL showed obvious anti-angiogenesis effect. Protein structure: Endostatin (ALA1571-Lys1754), Accession # P39060. | ||
| M13760 | 5(6)-CFDA | Cell Staining |
| 5-(6)-Carboxyfluorescein diacetate; CFDA | ||
| 5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) is a cell-permeant, amine-reactive green fluorescent probe used to stain cells for analysis in applications. (λex: 492 nm; λem: 517 nm). | ||
| M24797 | Remtolumab | TNF Receptor |
| ABT-122 | ||
| Remtolumab (ABT-122) is a dual-variable domain immunoglobulin that neutralises both tumor necrosis factor α (TNFα) and IL-17A. Remtolumab shows dual inhibition of TNFα and IL-17A. Remtolumab can be used for rheumatoid arthritis (RA) research. | ||
| M24913 | Spesolimab | IL Receptor/Related |
| BI 655130 | ||
| Spesolimab (BI 655130) is an anti-IL-36R antibody. IL-36 involves in immune system, as Spesolimab can be used for palmoplantar pustulosis (PPP) research. Spesolimab is associated with the reduction of biomarkers linked to innate, Th1/Th17, and neutrophilic pathways. | ||
| M25156 | Gumokimab | IL Receptor/Related |
| AK 111 | ||
| Gumokimab (AK 111) is a monoclonal antibody targeting IL-17A, which can be used in the study of psoriasis, ankylosing spondylitis. Gumokimab competitively blocks the binding of human IL-17A to IL-17R. | ||
| M29378 | MS177 | PROTAC |
| MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest. | ||
| M30097 | LB80317 | Anti-infection |
| LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment. | ||
| M30273 | Mini Gastrin I, human | Cholecystokinin Receptor |
| Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide. | ||
| M31025 | Mini Gastrin I, human TFA | Cholecystokinin Receptor |
| Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide. | ||
| M38822 | Kauran-16,17-diol | Apoptosis |
| Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages. | ||
| M40852 | Recombinant Human SIGLEC-10 Protein (HEK293, His Tag) | Recombinant Proteins |
| The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. | ||
| M41042 | SEQ-9 | Antibiotic |
| SEQ-9 is an orally active Mycobacterium tuberculosis (Mtb) 23S bacterial ribosome inhibitor with an IC50 of approximately 170 nM for unmethylated Mtb ribosomes. | ||
| M49403 | Relutrigine | Sodium Channel |
| PRAX-562 | ||
| Relutrigine is an orally active, persistent sodium channel inhibitor that potently and preferentially inhibits persistent INa induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC50 values of 141 nM and 75 nM, respectively. | ||
| M54284 | G12 | Others |
| G12 (Ras 5-17) is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). | ||
| M54715 | ZK53 | Mitochondrial Related |
| ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. | ||
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