About 18 results found for searched term "SIN-1 chloride" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7296 | SIN-1 chloride | Metabolite/Endogenous Metabolite |
| SIN-1 chloride is a water-soluble NO donor. | ||
| M8757 | TASIN-1 hydrochloride | Others |
| TASIN-1 (Truncated APC Selective INhibitor-1) targets EBP- (Emopamil-binding protein; D8-D7 sterol isomerase) dependent cholesterol biosynthesis and selectively induces cellular cholesterol depletion and apoptotic death in human colorectal cancer (CRC) cultures harboring APC truncations under lipid-deficient conditions (0. | ||
| M2593 | Siramesine hydrochloride | Sigma Receptor |
| Lu 28-179 | ||
| Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. | ||
| M5999 | Terazosin hydrochloride dihydrate | Adrenergic Receptor |
| TZ | ||
| Terazosin hydrochloride dihydrate is a selective, competitive and orally active α1-adrenoceptor antagonist. Terazosin is also an agonist of HSP90. Terazosin hydrochloride dihydrate can be used for the research of benign prostatic hyperplasia (BPH) and high blood pressure. | ||
| M7481 | W-7 hydrochloride | CaMK |
| W7 hydrochloride | ||
| W-7 Hydrochloride is a selective calmodulin antagonist. W-7 Hydrochloride inhibits Ca2+ -calmodulin-dependent phosphodiesterase and Myosin light chain kinase. The IC50 values were 28 μM and 51 μM, respectively. W-7 Hydrochloride can induce apoptosis and has anti-cancer activity. | ||
| M8038 | CP-154526 hydrochloride | CRFR |
| CP-154526 hydrochloride is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1) with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM). | ||
| M10599 | PF-543 HCl | SPHK |
| PF-543 HCl; PF543 hydrochloride | ||
| PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. | ||
| M16986 | Kobusin | GLUT |
| Kobusin, a dioxygenated lignan isolated from Pnonobio biondii Pamp, is also an activator of the CFTR and CaCCgie chloride channels and an inhibitor of the ANO1/CaCC (calcium-activated chloride channel) channel. | ||
| M28696 | Ozanimod hydrochloride | S1P Receptor |
| RPC-1063 hydrochloride | ||
| Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS) . | ||
| M28819 | AG-1478 hydrochloride | EGFR/HER2 |
| Tyrphostin AG-1478 hydrochloride; NSC 693255 hydrochloride | ||
| AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV). | ||
| M28828 | Alexidine dihydrochloride | Antifungal |
| Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. | ||
| M29002 | SLM6031434 hydrochloride | SPHK |
| SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research. | ||
| M31013 | MS31 trihydrochloride | Epigenetic Reader Domain |
| MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells. | ||
| M31016 | Bomedemstat dihydrochloride | Histone demethylase |
| IMG-7289 dihydrochloride | ||
| Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis. | ||
| M31017 | Bomedemstat hydrochloride | Histone demethylase |
| IMG-7289 hydrochloride | ||
| Bomedemstat (IMG-7289) hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat hydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat hydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis. | ||
| M31018 | KDOAM-25 trihydrochloride | Histone demethylase |
| KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. | ||
| M31059 | DPM-1001 trihydrochloride | Phosphatase |
| DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property. | ||
| M54755 | TRV055 hydrochloride | Angiotensin Receptor |
| TRV055 hcl | ||
| TRV055 hydrochloride, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 hydrochloride is efficacious in stimulating cellular Gq-mediated signaling. | ||
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