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Terazosin hydrochloride dihydrate is a selective, competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate can be used for the research of benign prostatic hyperplasia (BPH) and high blood pressure.
Terazosin is also an agonist of HSP90. Terazosin binds a new target, phosphoglycerate kinase 1 (Pgk1), and activates its enzymatic activity, probably through 2,4-diamino-6,7-dimethoxyisoquinoline's ability to promote ATP release from Pgk1. Mechanistically, the ATP generated from Pgk1 may enhance the chaperone activity of Hsp90, an ATPase known to associate with Pgk1. Upon activation, Hsp90 promotes multistress resistance. Terazosin promotes the expression of HSP90 and reduces the activity of iNOS. In addition, Terazosin up-regulates the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream gene γ-GCS, which improves the ability of theca cells to resist oxidative stress.
| Molecular Weight | 459.92 |
| Formula | C19H25N5O4.HCl.2(H2O) |
| CAS Number | 70024-40-7 |
| Solubility (25°C) | DMSO 26 mg/mL Water 10 mg/mL |
| Storage | 4°C, dry, sealed |
[2] Chen X, et al. Nat Chem Biol Terazosin activates Pgk1 and Hsp90 to promote stress resistance.
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