About 5 results found for searched term "SF 11" (0.055 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1925 | LY294002 | PI3K |
| NSC 697286; SF 1101 | ||
| LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. | ||
| M3007 | SF1126 | PI3K |
| SF1126 is the RGDS-conjugated precursor of LY294002 and the first-in-class dual PI3K/BRD4 pan-inhibitor with anti-tumor and anti-angiogenic activities. It also induces apoptosis. | ||
| M7289 | SF 11 | Neuropeptide Receptor |
| SF 11 is a nPY Y 2 receptor antagonist. | ||
| M15095 | Recombinant Mouse RANKL (HEK293, N-6His) | Cytokines and Growth Factors |
| Tnfsf11 | ||
| Recombinant Mouse RANKL/TNFSF11 is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation. | ||
| M55293 | Recombinant Mouse RANKL (E. coli) | Cytokines and Growth Factors |
| TNFSF11 | ||
| RANKL is a member of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. Tnfsf11 is involved in many fundamental biological processes, such as acting as a regulator of interactions between T cells and dendritic cells, regulating T cell-dependent immune responses and enhancing bone resorption in malignant humoral hypercalcemia. It enhances the ability of dendritic cells to stimulate the proliferation of naive T cells. | ||
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