About 9 results found for searched term "Rho-Kinase-IN-1" (0.275 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49536 | Rho-Kinase-IN-1 | ROCK |
| Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. | ||
| M1872 | Fasudil hydrochloride | ROCK |
| HA-1077; AT877 | ||
| Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM. | ||
| M5260 | Hydroxyfasudil hydrochloride | ROCK |
| HA-1100 HCl | ||
| Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively. | ||
| M5269 | GSK180736A | ROCK |
| GSK180736 | ||
| GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5. | ||
| M11034 | Netarsudil (AR-13324) 2HCl | ROCK |
| AR-13324 | ||
| Netarsudil (AR-13324) is a Rho-kinase (ROCK) inhibitor with Ki values of 0.2-10.3 nM with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow and lowers IOP via the trabecular pathway, and may be used in glaucoma-related studies. | ||
| M28062 | PF-4950834 | ROCK |
| PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration. | ||
| M28366 | Verosudil | ROCK |
| AR-12286 | ||
| Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork. | ||
| M41593 | Rho-Kinase-IN-3 | ROCK |
| Rho-Kinase-IN-3 is a potent and selective Rho kinase (ROCK1) inhibitor with an IC50 value of 8 nM. | ||
| M49531 | Glycyl H-1152 hydrochloride | ROCK |
| Glycyl H-1152 hydrochloride is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. | ||
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