About 7 results found for searched term "RK-33" (0.301 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6478 | AZ Dyrk1B 33 | Others |
| AZ Dyrk1B 33 is a potent and selective Dyrk1B kinase inhibitor. | ||
| M10506 | RK-33 | DNA/RNA Synthesis |
| RK33 | ||
| RK-33 is a first-in-class, potent and selective DDX3 (RNA helicase) inhibitor, it binds to DDX3 and abrogates its activity. | ||
| M14766 | SB-633825 | Others |
| SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis. | ||
| M20811 | XMD8-85 (ERK5-IN-1) | ERK |
| XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. | ||
| M21230 | GNF2133 | DYRK |
| GNF2133 is a potent, selective, orally active DYRK1A inhibitor with IC50s of 0.0062 and >50 µM for DYRK1A and GSK3β, respectively. GNF2133 has potential for the study of type 1 diabetes. | ||
| M21591 | RLX-33 | RXFP |
| RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36μM, 7.82μM and 13.86μM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome. | ||
| M28537 | CYH33 methanesulfonate | PI3K |
| CYH33 methanesulfonate is an orally active, highly selective PI3Kα inhibitor with IC50s of 5.9 nM/598 nM/78.7 nM/225 nM against α/β/δ/γ isoform, respectively. CYH33 methanesulfonate inhibits phosphorylation of Akt, ERK and induces significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells. CYH33 methanesulfonate has potent activity against solid tumors. | ||
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